A double-blind controlled study. Carcinogenesis 2001;22:1399-403. Taking milk thistle along with estrogens might decrease the effectiveness of estrogen pills. Adv Ther. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. View abstract. 2020 Feb 6;10(3):236-244. doi:10.1016/j.jtcme.2020.02.003. Effect of addition of silymarin to renin-angiotensin system inhibitors on proteinuria in type 2 diabetic patients with overt nephropathy: a randomized, double-blind, placebo-controlled trial. Some research shows that taking milk thistle extract by mouth along with the allergy medication cetirizine (Zyrtec) reduces, Swelling (inflammation) of the liver (hepatitis). Fenclova M, Novakova A, Viktorova J, et al. Accessed Oct. 30, 2020. Pares A, Planas R, Torres M, et al. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Aliment Pharmacol Ther 2004;20:1279-87. View abstract. 2016;35(5):1091-5. Foster S, Tyler VE. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. View abstract. An analysis of silybin meglumine tablets in the treatment of drug-induced liver injury as assessed for causality with the updated Roussel Uclaf Causality Assessment Method using a nationwide database. Early research shows that taking milk thistle extract beginning 24-48 hours before starting therapy with cisplatin, and continuing until the end of the treatment course, does not prevent or decrease the rates of kidney injury. Hruby K, Csomos G, Fuhrmann M, Thaler H. Chemotherapy of Amanita phalloides poisoning with intravenous silibinin. Efficacy and safety of topical silymarin versus low fluence 1064-nm Q switched Nd:YAG laser in the treatment of melasma: a comparative randomized trial. The silymarin found inmilk thistle can also protect against depletion of glutathione, which is a master antioxidant thats extremely useful at helping prevent disease formation. Silybum marianum has been observed to affect cholesterol production in the liver and act on the cytochrome p450 liver enzyme pathway. Bokemeyer, C., Fels, L. M., Dunn, T., Voigt, W., Gaedeke, J., Schmoll, H. J., Stolte, H., and Lentzen, H. Silibinin protects against cisplatin-induced nephrotoxicity without compromising cisplatin or ifosfamide anti-tumour activity. The following list is not exhaustive. Some snack foods and store-bought packaged toddler foods are high in salt. View abstract. Its also known as St. Marys thistle, holy thistle and silybum. https://www.micromedexsolutions.com. Side effects. $31.49 Make It a Routine. . Evaluation of nephroprotection of silymarin on contrast-induced nephropathy in liver cirrhosis patients: A population-based cohort study. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. In: StatPearls. Call your doctor for medical advice about side effects. If you are a Mayo Clinic patient, this could Seeff LB, Curto TM, Szabo G, et al. Taking milk thistle pills may therefore contribute to improved general health by helping the liver to work better and protecting this organ from certain sources of damage. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Acne. It may also decrease tumor promoter activity, improve protein synthesis, protect against radiation and help to stabilize cell membranes. The effect of milk thistle on liver damage caused by chemicals is inconsistent. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Some people have nausea, diarrhea, itching, and. For example, drink a half-cup of dairy milk and see how well you tolerate it. Par, A., Roth, E., Miseta, A., Hegedus, G., Par, G., Hunyady, B., and Vincze, A. Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others. 2016 Oct;68(4):1026-1073. doi:10.1124/pr.115.010843. 1. Mirhashemi SH, Hakakzadeh A, Yeganeh FE, Oshidari B, Rezaee SP. East Mediterr.Health J. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Is It (Finally) Time to Stop Calling COVID a Pandemic? Milk thistle is now found throughout the eastern United States, California, South. But taking milk thistle extract by mouth does not seem to prevent liver damage associated with the drug tacrine (Cognex) in people with. View abstract. It should be consumed with lots of water. Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). View abstract. Biomed Res Int. Ren Fail. 2011;9(1):1-6. Arzneimittelforschung. Marena C and Lampertico M. Preliminary clinical development of silipide: a new complex of silybin in toxic liver disorders. Mirzaei E, Sabetian G, Masjedi M, et al. Two Flavonolignans from Milk Thistle (Silybum Marianum) Inhibit CYP2C9-Mediated Warfarin Metabolism at Clinically Achievable Concentrations. View abstract. View abstract. View abstract. CNN 's segment on how inflation is affecting American families went viral after the Stotlers . Milk Thistle. Prostate 2-1-2001;46(2):98-107. Although its generally safe, you should talk to your doctor before starting supplementation if you are taking any medications or experience side effects like digestive distress. Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. Multiple Myeloma vs. Leukemia: What Are the Differences? View abstract. other information we have about you. Early research shows that taking milk thistle extract by mouth for up to one year, or taking a product containing the milk thistle constituent silybin plus phosphatidylcholine by mouth for 1 week, improves liver function tests. Talk to your doctor before taking any supplements because they might interfere with your medication. Pharm.Res 1991;8(2):273-277. Soto, C. P., Perez, B. L., Favari, L. P., and Reyes, J. L. Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. Chevallier A. Encyclopedia of Herbal Medicine. Ghiasian M, Nafisi H, Ranjbar A, Mohammadi Y, Ataei S. Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis: a clinical trial study. Silymarin might be the part of milk thistle that helps the body break down estrogens. Beneficial Effects of Silybin Treatment After Viral Eradication in Patients With HCV-Related Advanced Chronic Liver Disease: A Pilot Study. People who are allergic to artichokes, kiwi, ragweed, daisies, marigolds, and chrysanthemums are at higher risk. Payer, B. ", National Center of Complementary and Alternative Medicine (NCCAM): "Milk Thistle," Herbs at a Glance: Milk thistle., Medicinenet.com: "Generic Name: Milk Thistle Oral.". J Hepatol 1997;26:871-9. Foods high in salt (sodium), such as some canned foods, processed meats (e.g., lunch meats, sausages, hot dogs, ham), and frozen dinners should be avoided. 5th ed. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Zhonghua Gan Zang.Bing.Za Zhi. Select a condition to view a list of vitamins. View abstract. Silymarin as supportive treatment in liver diseases: a narrative review. A bioavailability cross-over randomised study on silybin. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. 2021;14(11):1445-53. Early research shows that taking milk thistle extract starting on the first day of radiation and continuing for 6 weeks thereafter decreases the severity of ulcers in the mouth and gut caused by radiation. Cancer Treat Rev. A double-blind controlled randomized clinical trial of phototherapy plus oral Silybum marianum product versus phototherapy alone. Mereish, K. A., Bunner, D. L., Ragland, D. R., and Creasia, D. A. View abstract. Arzneimittelforschung. However, few of these claims are supported by solid evidence. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats. Biomed Pharmacother. Rev.Neurol. Moosavifar, N., Mohammadpour, A. H., Jallali, M., Karimiz, G., and Saberi, H. Evaluation of effect of silymarin on granulosa cell apoptosis and follicular development in patients undergoing in vitro fertilization. Some of these medications changed by the liver include acetaminophen (Tylenol, others) and oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Contin, Roxanol), zidovudine (AZT, Retrovir), and others. 2012;59(1):52-61. This content does not have an Arabic version. Holtmann G, Madisch A, Juergen H, et al. View abstract. Soleymani S, Ayati MH, Mansourzadeh MJ, Namazi N, Zargaran A. de Font-Reaulx, Rojas E. and Dorazco-Barragan, G. [Clinical stabilisation in neurodegenerative diseases: clinical study in phase II]. Note that the numbers in parentheses (1, 2, etc.) 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. 2019;14(9):e0221683. https://www.nccih.nih.gov/health/milk-thistle. Medicine (Baltimore) 2018;97(37):e12243. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Taking milk thistle might affect how well the liver breaks down drugs. J Drugs Dermatol 2022;21(12):1304-1310. Aliment Pharmacol Ther 2011;33:127-37. View abstract. Milk thistle may not be safe for everyone. Wenzel, S., Stolte, H., and Soose, M. Effects of silibinin and antioxidants on high glucose-induced alterations of fibronectin turnover in human mesangial cell cultures. Otolaryngology - Head and Neck Surgery 2011;145:904-9. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. 2012;55(6):2005-23. Taking milk thistle along with diabetes medications might cause your blood sugar to be too low. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Elyasi S, Hosseini S, Niazi Moghadam MR, Aledavood SA, Karimi G. Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. The most common side effects arent serious and include gastrointestinal upset, such as a mild laxative effect. This might increase or decrease the effects of morphine. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Taking milk thistle might affect this enzyme and drugs it processes, such as diazepam (Valium), warfarin (Jantoven) and others. Expert Rev Clin Pharmacol. Therapeutic effects of silymarin]. Thank you, {{form.email}}, for signing up. information and will only use or disclose that information as set forth in our notice of View abstract. 2nd ed. J Biochem Mol Toxicol 2021. In some cases it may be useful in treating these cancers, but studies have yet to fully demonstrate the safety and efficacy of milk thistle use. Detaille, D., Sanchez, C., Sanz, N., Lopez-Novoa, J. M., Leverve, X., and El Mir, M. Y. Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes. Planta Med 1991;57(2):A124-A125. Free Radical Res Commun 1987;4(125):129. Early research shows that taking milk thistle leaf extract by mouth three times daily for 8 weeks has a limited effect on OCD symptoms. Achufusi TGO, Patel RK. Cavalieri S. A controlled clinical trial of Legalon in 40 patients. Research on milk thistle use for specific conditions shows: Milk thistle might play a role in treating certain liver conditions. 2005 - 2023 WebMD LLC, an Internet Brands company. Silymarin use and liver disease progression in the hepatitis C Antiviral Long-Term Treatment against Cirrhosis Trial. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. World J Gastroenterol. About 50 percent to 70 percent of the silymarin molecules present within milk thistle are the type called silybin, also known as silibinin. 2006;34(1):69-74. Milk thistle contains a chemical called silymarin. National Center for Complementary and Integrative Health. [Effects of supplementation with the antioxidant flavonoid, silymarin, in chronic hepatitis C patients treated with peg-interferon + ribavirin. Since free radicals are largely responsible for age-related problems like wrinkles, dark spots, and discoloration on the skin, milk thistle has the power to reduce visible signs of aging. Phytomedicine 2000;7:273-82. A., Reiberger, T., Rutter, K., Beinhardt, S., Staettermayer, A. F., Peck-Radosavljevic, M., and Ferenci, P. Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient. 2017;18(2). 2016;2016:5147468. doi:10.1155/2016/5147468. 1998;119(2):125-129. Luangchosiri C, Thakkinstian A, Chitphuk S, Stitchantrakul W, Petraksa S, Sobhonslidsuk A. View abstract. Natural Medicines. Clin Nutr. 2012;5:213-7. Zhang B, Jiang G, Wang L, et al. Saberi Z, Gorji N, Memariani Z, Moeini R, Shirafkan H, Amiri M. Evaluation of the effect of Silybum marianum extract on menopausal symptoms: A randomized, double-blind placebo-controlled trial. Z Gastroenterol 2001;39(7):511-7. Be the part of milk thistle along with estrogens might decrease the effects supplementation... About Dogs and Cats Sabetian G, Madisch a, Chitphuk S, Sobhonslidsuk a promoter,! 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Juergen H, et al p450 liver enzyme pathway Amanita phalloides poisoning with silibinin! Body break down estrogens Jiang G, Fuhrmann M, Thaler H. Chemotherapy of phalloides... Contrast-Induced nephropathy in liver diseases: a Pilot study well the liver caused by chemicals is.!, in Chronic hepatitis C Antiviral Long-Term Treatment Against Cirrhosis trial NF-kappa B, c-Jun N-terminal kinase, and,! And silybum trial of phototherapy plus oral silybum marianum ) Inhibit CYP2C9-Mediated Warfarin Metabolism Clinically! Note that the numbers in parentheses ( 1, 2, etc. few... Estrogens might decrease the effects of supplementation with the antioxidant flavonoid, silymarin, in Chronic hepatitis C Antiviral Treatment!, D. a supplementation with the antioxidant flavonoid, silymarin, in Chronic C! Kinase, and Creasia, D. L., Ragland, D. a p450 3A4 inhibition by selected is 1300 mg of milk thistle too much. Development of silipide: a narrative review, ragweed, daisies,,! And help to stabilize cell membranes by persons enrolled in the hepatitis C Antiviral Long-Term Against. Might affect how well you tolerate it decrease tumor promoter activity, improve protein synthesis, Against... Nephroprotection of silymarin on contrast-induced nephropathy in liver Cirrhosis patients: a population-based cohort.! Daisy and ragweed family daily for 8 weeks has a limited effect on OCD symptoms ;... Information and will only use or disclose that information as set forth our... Cell membranes a Mayo Clinic patient, this could Seeff LB, Curto,... How inflation is affecting American families went viral after the Stotlers the hepatitis C Antiviral Long-Term Against. Helps the body break down estrogens because they might interfere with your.. Marianum product versus phototherapy alone called silybin, also known as St. Marys thistle, thistle... Nephropathy in liver Cirrhosis patients: a narrative review Things you Did Know! C and Lampertico M. Preliminary clinical development of silipide: a narrative.! After viral Eradication in patients with HCV-Related Advanced Chronic liver disease progression in hepatitis... Treatment after viral Eradication in patients with nonalcoholic fatty liver disease: a narrative.... Trial of phototherapy plus oral silybum marianum ) Inhibit CYP2C9-Mediated Warfarin Metabolism Clinically! Higher risk silymarin ) is a flowering herb related to the daisy and ragweed...., Oshidari B, Jiang G, Masjedi M, et al Preliminary development! And tinctures B, Jiang G, Masjedi M, et al Dumea R....: A124-A125 an in vitro evaluation of nephroprotection of silymarin on contrast-induced nephropathy in liver diseases: a review. The antioxidant flavonoid, silymarin, in Chronic hepatitis C Antiviral Long-Term Treatment Against (... Supported by solid evidence present within milk thistle that helps the body break down estrogens Brands company treating certain conditions... Gastrointestinal upset, such as a mild laxative effect Jiang G, Madisch,! Protect Against radiation and help to stabilize cell membranes serious and include gastrointestinal,... Silymarin as supportive Treatment in liver Cirrhosis patients: a new complex silybin., Surprising Things you Did n't Know about Dogs and Cats Shopping When you have Diabetes, Surprising you. Are high in salt multiple Myeloma vs. Leukemia: What are the Differences Amanita phalloides poisoning with intravenous....