2010;24(3):183-188. Appl.Environ.Microbiol. Contact Dermatitis 1980;6(5):356-357. View abstract. Hirsch, K., Danilenko, M., Giat, J., Miron, T., Rabinkov, A., Wilchek, M., Mirelman, D., Levy, J., and Sharoni, Y. ", Kew Science, Plants of the World Online: "Allium sativum L.", L. Bayan et al., Avicenna Journal of Phytomedicine, "Garlic: a review of potential therapeutic effects. Am J Clin Nutr 1997;65:445-50. 1994;44(6):734-743. When taken by mouth, garlic can cause bad breath, a burning sensation in the mouth or stomach, heartburn, gas, nausea, vomiting, body odor, and diarrhea. 2008. 2016;65(3):353-5. View abstract. View abstract. Dirsch VM, Kiemer AK, Wagner H, Vollmar AM. Imai J, Ide N, Nagae S, et al. J Am Acad.Nurse Pract. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. Hype about glucosamine. View abstract. View abstract. Int J Dermatol 2021 Feb 11. doi: 10.1111/ijd.15430. Phytother Res 2021;35(11):6335-6342. 2009;32(3):191-203. Some studies have associated garlic and other members of the Allium family with a reduced risk of certain cancers. Alexandra enjoys Ravi Teja Tadimalla is an editor and a published author. Suppression of LDL oxidation by garlic. View abstract. Investigation of garlic-induced apoptosis in breast cancer cell lines [poster presentation]. A., Martirosyan, D. M., and Orekhov, A. N. The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease. J Pharm Pharmacol 1997;49:908-11. View abstract. Vaginal yeast infections (thrush): What helps? Staba EJ, Lash L, Staba JE. This is especially likely if you are eating more garlic Zhou X, Qian H, Zhang D, Zeng L. Garlic intake and the risk of colorectal cancer: A meta-analysis. Search more ingredients for nutritional information: 2005 - 2023 WebMD LLC, an Internet Brands company. Kandziora J. Blutdruck and lipidsenkende Wirkung eines Knoblauch-praparates in kombination mit einem Diuretikum. Prolonged contact with garlic may cause skin irritation. J Epidemiol 1999;9:297-305. Lets get started. 2000;95(1):309. It can also cause heartburn, upset stomach, and diarrhea. Can J Cardiol 2011;27(4):488-505. Cohain, J. S. Long-term symptomatic group B streptococcal vulvovaginitis: eight cases resolved with freshly cut garlic. J Natl Cancer Inst 2006;98:974-83. Ruocco, V et al. Clin.Nutr. Appl Environ.Microbiol 1996;62(11):4238-4242. Ceska.Slov.Farm. Results of a 3-year treatment with garlic extract on the reinfarction and mortality rate]. Aged garlic extract attenuates intracellular oxidative stress. Appl Environ Microbiol 2000;66:2269-73. J Natl Cancer Inst 2002;94:1648-51.. View abstract. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Carcinogenesis 1996;17:477-84. Andrianova, I. V., Sobenin, I. View abstract. Eur Phytojournal 2001;Symposium posters(1):1. Effects of garlic extract on platelet aggregation: a randomized placebo-controlled double-blind study. BMJ Case Rep 2014. Gardner CD, Chatterjee L, and Carlson J. Saudi.Med J 2003;24(8):842-845. These side effects are often worse with raw garlic. View abstract. One of the many other side effects of garlic during pregnancy is that it can also decrease the absorption capacity of iodine and cause hypothyroidism. Garlic.Garlic an Overview | ScienceDirect Topics. Duncan A, Mills J. View abstract. By clicking Subscribe, I agree to the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats. Although garlic is a healthy addition to a balanced diet, eating too much may cause several side effects. One of the most serious side effects of eating too much garlic is an increased risk of bleeding, especially if youre taking blood thinners or undergoing surgery. View abstract. Br J Cancer 2022;126(12):1755-1764. 2004;117(8):1155-1160. Relationship between consumption of raw garlic and handgrip strength in a large-scale adult population. Gebhardt R, Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Reduced allergy rates in atopic eczema to contact allergens used in both skin products and foods: atopy and the 'hapten-atopy hypothesis'. Swanson, C. A., Mao, B. L., Li, J. Y., Lubin, J. H., Yao, S. X., Wang, J. J Med Assoc Thai 2003;86:750-7. Horie T, Matsumoto H, Kasagi M, et al. Arzneimittelforschung. View abstract. Blood Coagul.Fibrinolysis 2001;12(1):67-74. Qureshi A, Abuirmeileh N, Din Z, and et al. Gebhardt R and Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Diabetes Metab Syndr Obes. Lipids Health Dis. 1987;8(2):79-85. Bleumink, E. and Nater, J. P. Contact dermatitis to garlic; crossreactivity between garlic, onion and tulip. J Ethnopharmacol. Siegers CP, Steffen B, Robke A, and et al. Atherosclerosis 1977;28(2):155-159. Ter.Arkh. ", American Academy of Family Physicians: "Health Effects of Garlic.". Zhang, X. H., Lowe, D., Giles, P., Fell, S., Board, A. R., Baughan, J. Moosavian SP, Paknahad Z, Habibagahi Z. Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Gastroenterology 1996;110(1):12-20. 2006;136(3 Suppl):821S-826S. Burnham BE. View abstract. Can.J.Gastroenterol. Brosche, T., Platt, D., and Dorner, H. The effect of a garlic preparation on the composition of plasma lipoproteins and erythrocyte membranes in geriatric subjects. Save the high-quality PDF version on your device now. Galduroz, J. C., Antunes, H. K., and Santos, R. F. Gender- and age-related variations in blood viscosity in normal volunteers: a study of the effects of extract of Allium sativum and Ginkgo biloba. Pharmacology 2006;77:100-4. 2011;315(2):87-93. Clinical assessment of potential cytochrome P450-mediated herb-drug interactions. Delaha, E. C. and Garagusi, V. F. Inhibition of mycobacteria by garlic extract (Allium sativum). Farnsworth N, Bingel A, Cordell G, et al. View abstract. Experientia 2-15-1996;52(2):115-120. Orekhov AN, Sobenin IA, Korneev NV, et al. View abstract. Khodavandi, A., Alizadeh, F., Harmal, N. S., Sidik, S. M., Othman, F., Sekawi, Z., and Chong, P. P. Expression analysis of SIR2 and SAPs1-4 gene expression in Candida albicans treated with allicin compared to fluconazole. Onion and garlic intake and breast cancer, a case-control study in Puerto Rico. 2003;15(3):120-129. Epidemiology 1997;8:658-65. 2015;28(3):414-23. J Int Soc Sports Nutr 2013;10(1):22. Bordia, A., Verma, S. K., and Srivastava, K. C. Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease. Forsch.Komplementmed. Nature 4-6-2000;404(6778):542. Indian J Physiol Pharmacol 1979;23:211-214. Available for Android and iOS devices. View abstract. Anticancer Drugs 1998;9(3):291-294. 2009;89(1):257-264. View abstract. View abstract. de Rooij, B. M., Boogaard, P. J., Rijksen, D. A., Commandeur, J. N., and Vermeulen, N. P. Urinary excretion of N-acetyl-S-allyl-L-cysteine upon garlic consumption by human volunteers. Z., and Li, B. Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C. Acta Pharmacol.Sin. View abstract. View abstract. View abstract. Myneni AA, Chang SC, Niu R, et al. Zhou, Y., Zhuang, W., Hu, W., Liu, G. J., Wu, T. X., and Wu, X. T. Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis. WebMD does not provide medical advice, diagnosis or treatment. 2004;94(1):155-158. Garty BZ. Orekhov A and Tertov V. In vitro effect of garlic powder extract on lipid content in normal and atherosclerotic human aortic cells. A., Krzhivitskii, P. I., Semiglazov, V. F., Aleksandrov, V. A., Sobenin, N. A., and Orekhov, A. N. [Study of an antioxidant dietary supplement "Karinat" in patients with benign breast disease]. View abstract. An intervention study to prevent gastric cancer by micro-selenium and large dose of allitridum. A multicenter placebo-controlled double-blind study. View abstract. 2019;181(6):591-602. Blumenthal M, Goldberg A, Brinckmann J, eds. 2020;39(4):1234-1241. View abstract. Balasenthil, S., Ramachandran, C. R., and Nagini, S. Prevention of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis by garlic. View abstract. Kosuge, Y., Koen, Y., Ishige, K., Minami, K., Urasawa, H., Saito, H., and Ito, Y. S-allyl-L-cysteine selectively protects cultured rat hippocampal neurons from amyloid beta-protein- and tunicamycin-induced neuronal death. View abstract. Clin Res Hepatol Gastroenterol 2012;36(6):e134. This is not recommended. Garlic is high in fructans. Daily supplementation with aged garlic extract, but not raw garlic, protects low density lipoprotein against in vitro oxidation. Antimicrob.Agents Chemother. Lembo, G., Balato, N., Patruno, C., Auricchio, L., and Ayala, F. Allergic contact dermatitis due to garlic (Allium sativum). Vopr.Onkol. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Regulation of oxidative stress-mediated apoptosis by diallyl sulfide in DMBA-exposed Swiss mice. Adachi, A. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Heart 2000;83(suppl 2):A4. J Diet Suppl 2018;15(4):499-506. doi: 10.1080/19390211.2017.1358233. 2004;266(1-2):109-115. Oi, Y., Kawada, T., Shishido, C., Wada, K., Kominato, Y., Nishimura, S., Ariga, T., and Iwai, K. Allyl-containing sulfides in garlic increase uncoupling protein content in brown adipose tissue, and noradrenaline and adrenaline secretion in rats. View abstract. Baluchnejadmojarad, T. and Roghani, M. Endothelium-dependent and -independent effect of aqueous extract of garlic on vascular reactivity on diabetic rats. J Nutr 2001;131(3s):1027S-1031S. Alliaceous migraines. 3-21-1990;82(6):478-485. Lee TY, Lam TH. Bojs, G. and Svensson, A. Are You Aware Of The 3 Major Side Effects Of Oil Pulling? Nutrition 2013;29(1):71-75. Wargovich, M. J. Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer. 2022 Jul 14;2022:6620661. View abstract. Garlic has antiplatelet effects and may increase bleeding during surgery (14). J Ethnopharmacol. Wang, Y., Zhang, L., Moslehi, R., Ma, J., Pan, K., Zhou, T., Liu, W., Brown, L. M., Hu, Y., Pee, D., Gail, M. H., and You, W. Long-term garlic or micronutrient supplementation, but not anti-Helicobacter pylori therapy, increases serum folate or glutathione without affecting serum vitamin B-12 or homocysteine in a rural Chinese population. Nutrition 2000;16:236-9. View abstract. StyleCraze provides content of general nature that is designed for informational purposes only. View abstract. The following two tabs change content below. JAMA 2000;284:831. Gu Y, Zhang S, Wang J, et al. Bagga, S., Thomas, B. S., and Bhat, M. Garlic burn as self-inflicted mucosal injury--a case report and review of the literature. J Clin Pharm.Ther 2009;34:133-45. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. Garlic and the strabismus surgeon. 2020;13:2389-2397. It also is better to stop garlic consumption at least 7 days before a scheduled surgery. Gallwitz, H., Bonse, S., Martinez-Cruz, A., Schlichting, I., Schumacher, K., and Krauth-Siegel, R. L. Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies. Prev.Med 1987;16(5):670-685. Contact allergy to garlic used for wound healing. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Controlled double-blind study of subjects with reduced HDL2-cholesterol]. ", J. Borlinghaus et al., Molecules: "Allicin: chemistry and biological properties. Schiermeier, Q. German garlic study under scrutiny. Ernst, E. Complementary/alternative medicine for hypertension: a mini-review. Pinto, J. T., Qiao, C., Xing, J., Rivlin, R. S., Protomastro, M. L., Weissler, M. L., Tao, Y., Thaler, H., and Heston, W. D. Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Br J of Clin Prac 1990;69:24-29. J Pharm.Pharmacol. However, it is much more likely that you will want to stop eating garlic well before reaching this threshold. Phytother Res 2021 Jan 23. doi: 10.1002/ptr.7021. O'Gara EA, Hill DJ, Maslin DJ. Ugeskr.Laeger 12-11-2000;162(50):6853-6854. Hyphema may also cause permanent vision loss. Pediatr Res 1993;34:805-8. Eur J Endocrinol. The effects of oral garlic on vaginal candida colony counts: a randomised placebo controlled double-blind trial. Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel. View abstract. View abstract. Am J Epidemiol. McFadden, J. P., White, I. R., and Rycroft, R. J. Allergic contact dermatitis from garlic. Jafari F, Tabarrai M, Abbassian A, Jafari F, Ayati MH. Br.J Clin Pract.Suppl 1990;69:30-35. View abstract. 2016;146(2):389S-396S. Tanaka, S., Haruma, K., Kunihiro, M., Nagata, S., Kitadai, Y., Manabe, N., Sumii, M., Yoshihara, M., Kajiyama, G., and Chayama, K. Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study. Garlic may also cause a condition called pemphigus, an autoimmunei XA condition in which the immune system cannot differentiate between healthy cells and foreign cells and attacks its own body cells. Pediatr.Pulmonol. A historical perspective on garlic and cancer. Anon. Controlled Clin Trials 1998;19:352-369. View abstract. JAMA 11-11-1998;280(18):1568. Dietary supplement interactions with antiretrovirals: a systematic review. 2005;19(1):84-89. 2009;(3):CD006206. Factorial trial of three interventions to reduce the progression of precancerous gastric lesions in Shandong, China: Design issues and initial data. Sobenin, I. It may lead to abdominal pain, bloating, and gas in some people. View abstract. Garlic may interact with medications such as blood thinners. The Iowa Womens Health Study, which included more than 40,000 women aged between 55 and 69, found that garlic consumption may decrease the risk of developing colon cancer. 2005;155(17-18):386-391. View abstract. View abstract. The healthiest way to eat garlic is in its raw form. View abstract. Improves heart health. View abstract. Lau BH, Lam F, Wang-Cheng R, and et al. Borrelli F, Capasso R, Izzo AA. Curr.Med Res Opin. A., Andrianova, I. V., Demidova, O. N., Gorchakova, T., and Orekhov, A. N. Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study. Qidwai, W., Qureshi, R., Hasan, S. N., and Azam, S. I. Takasu, J., Uykimpang, R., Sunga, M. A., Amagase, H., and Niihara, Y. View abstract. Gerodontology. 2001;22(2):132-136. Koscielny J, Klussendorf D, Latza R, et al. Chin Med.J.(Engl.) Apitz-Castro, R., Escalante, J., Vargas, R., and Jain, M. K. Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets. Kandziora J. Antihypertensive Wirksamkeit und Vertraglichkeit eines Knoblauch-preparates. View abstract. 2007;99(4):925-932. Garlic tea retains the health benefits of raw garlic, as long as it is prepared properly: the key is boiling your crushed garlic no longer than 3 minutes. B., Vinjamury, S. P., Der-Martirosian, C., Kubik, E., Mishra, L. C., Shepard, N. P., Singh, V. J., Meier, M., and Madhu, S. G. Ayurvedic and collateral herbal treatments for hyperlipidemia: a systematic review of randomized controlled trials and quasi-experimental designs. The potential application of Allium sativum (garlic) for the treatment of bladder cancer. Mane SK, Jordan PA, Bahna SL. J Appl.Bacteriol. Antimicrob.Agents Chemother 1985;27(4):485-486. We comply with the HONcode standard for trustworthy health information. Planta Med 2000;66:148-51. 2006;20(1):21-27. Association between dietary raw garlic intake and newly diagnosed nonalcoholic fatty liver disease: a population-based study. Fitoterapia 2001;72(5):524-531. 2015;24(4):575-82. Gerontology 2008;54(3):173-176. Dorant E, van den Brandt PA, Goldbohm RA. Vopr.Onkol. Neurosurgery 1990;27(4):659. 2-11-1999;42(3):364-372. View abstract. Bulb dermatitis. Lipids Health Dis. Planta Med 1999;65:545-8. Kasuga, S., Uda, N., Kyo, E., Ushijima, M., Morihara, N., and Itakura, Y. Pharmacologic activities of aged garlic extract in comparison with other garlic preparations. View abstract. Evans V. Herbs and the brain: friend or foe? Common side effects (especially when eating raw garlic) may include: unpleasant breath or body odor; heartburn, burning in your mouth or throat; nausea, View abstract. Ried, Karin et al. 2019 Jun 19. Huang, J., Frohlich, J., and Ignaszewski, A. P. The impact of dietary changes and dietary supplements on lipid profile. Arch.Toxicol 1996;70(10):635-639. View abstract. Garlic as a tick repellent. A systematic review and metaanalysis on the effects of garlic preparations on blood pressure in individuals with hypertension. View abstract. View abstract. Contact Dermatitis 2002;47(1):48. Chinese Journal of Clinical Oncology 1998;25(5):338-340. Arch Dermatol.Res 2003;295(3):117-123. View abstract. Tanamai, J., Veeramanomai, S., and Indrakosas, N. The efficacy of cholesterol-lowering action and side effects of garlic enteric coated tablets in man. View abstract. View abstract. Morales-Gonzlez, Jos Antonio et al. View abstract. However, some studies have suggested that raw garlic may be more effective than the cooked version, while garlic supplements are the most effective. Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial. Pharmazie 2004;59(1):10-14. McHugh CP. View abstract. Witte JS, Longnecker MP, Bird CL, et al. Garlic could trigger heartburn and irritate the digestive tract. Xiao, D., Pinto, J. T., Soh, J. W., Deguchi, A., Gundersen, G. G., Palazzo, A. F., Yoon, J. T., Shirin, H., and Weinstein, I. Mader FH. Am J Med 1993;94:632-5. Peleg, A., Hershcovici, T., Lipa, R., Anbar, R., Redler, M., and Beigel, Y. Am.J Clin Nutr. 2001;131(3s):951S-954S. Dizziness or weakness. Ma, J. L., Zhang, L., Brown, L. M., Li, J. Y., Shen, L., Pan, K. F., Liu, W. D., Hu, Y., Han, Z. X., Crystal-Mansour, S., Pee, D., Blot, W. J., Fraumeni, J. F., Jr., You, W. C., and Gail, M. H. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. Biochim Biophys Acta 1994;1213(1):57-62. Pediatr Dermatol. View abstract. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This can show up as bloating, diarrhea and pain in the stomach. Srivastava KC, Bordia A, and Verma SK. Ried K. Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: An updated meta-analysis and review. Wang, B. H., Zuzel, K. A., Rahman, K., and Billington, D. Protective effects of aged garlic extract against bromobenzene toxicity to precision cut rat liver slices. There is no research to support that garlic can elevate blood pressure levels. View abstract. Adler AJ, Holub BJ. Tokyo, Japan: Springer-Verlag;1997. Clin Pharmacol Ther 2003;74:170-7.. View abstract. Saradeth T, Seidl S, Resch KL, and et al. Kim H, Keum N, Giovannucci EL, Fuchs CS, Bao Y. Garlic intake and gastric cancer risk: results from two large prospective US cohort studies. Berthold HK, Sudhop T, von Bergmann K. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism. It may also lower blood pressure and interact with certain medications. 2-16-2011;1374:110-115. J Nutr. Lipids 1996;31:1269-76. 2005;35(2):99-100. Call your doctor for medical advice about side effects. Arerugi 2010;59(5):545-551. It is commonly used for conditions related to the. A., and Pinto, P. L. [Treatment of ascaridiasis with garlic (Allium sativum)]. View abstract. J Gen.Microbiol. Dent Traumatol 2022. This might decrease how well isoniazid works. B., and Eling, T. E. Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells. 2004;50(4):467-472. Horie T, Awazu S, Itakura Y, Fuwa T. Alleviation by garlic of antitumor drug-induced damage to the intestine. 1995;34(4):278-279. Fortschr.Med 12-20-1990;108(36):703-706. Li, M., Min, J. M., Cui, J. R., Zhang, L. H., Wang, K., Valette, A., Davrinche, C., Wright, M., and Leung-Tack, J. Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage. Ashraf, M. Z., Hussain, M. E., and Fahim, M. Endothelium mediated vasorelaxant response of garlic in isolated rat aorta: role of nitric oxide. Applies to garlic: oral capsule, oral tablet. Anecdotal evidence suggests certain other side effects of garlic too. This can help prevent some indigestion and gas.. Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study.