Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. Antibiotics that work on germs inside and outside of cells include the tetracyclines, macrolides, rifamycins, and azoles. 2nd day: 3 x 4 drops per day. It is a nutrient found in iodized salt, seafood, or seaweed. Front Med (Lausanne). He eats mostly Paleo, organic foods and herbs and supplements, but I believe it is the biofilm that hides from all treatments. Byron White is a combination product with multiple formulations using many herbs and extracts. Some prescription antibiotics can be given using pulse dosing. In 2018, an in vitro (in culture cells) study suggested that 10 plant-derived essential oils could help fight off B. burgdorferi. This herbal comes in cat, dog, human and horse doses. It is by no means comprehensive. doi:10.1128/AAC.00864-15, Zheng X, Ma X, Li T, Shi W, Zhang Y. I will not be talking further about iodine since the focus of this article is on herbs specifically. I find either benzathine penicillin G (Bicillin LA) 1.2 million units given 3-4 times a week or high dose oral amoxicillin 500 mg 3-4 pills given 3 times a day is nearly as effective as IV antibiotic regimens. Med., 21 February 2020. It was first described with the use of penicillin treatment for syphilis. Insect vectors such as mosquito, are also believed to act as a host to the Lyme causing bacterium. . Any labs in Europe you can recommend? Currently, healthcare professionals choose between three antibiotics in the treatment of Lyme disease. I initially used the one recommended by Buhner and would take 3 - 3x per day. Japanese Knotweed (Fallopia japonica, or You Ji Hu Zhang in Chinese) is native to eastern Asia. About 20% of patients will experience this. Working with a knowledgeable naturopath or md to use herbs and diet is suggested. Tetracyclines and macrolides both block protein production by binding to the protein production apparatus in germs called ribosomes. Japanese knotweed (Polygonum cuspidatum) Oregano oil; Cinnamon bark essential oil; Clove essential oil; Of note, this is one of the first studies to show that Cryptolepis has activity against the Lyme spirochete. Some of it sounds like addisons You got me curious! Treating Borrelia, the Lyme germ, with antibiotics is complicated because limited research shows which treatment regimens work best. Since Borrelia adapts for self-protection and two-weeks of antibiotics is often not sufficient, exploring herbals provides some additional ways to treat Lyme disease. Light treatment. Japanese knotweed is a traditional medicine in India and China that contains the polyphenol resveratrol. There are no dosage suggestions available for weight loss planning. It may be more effective than continuous regimens. Study 1: Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Persistent Forms of Borrelia, Source: Goc, Anna & Niedzwiecki, Aleksandra & Rath, Matthias. Interaction of Flavones From the Roots of Scutellaria Baicalensis With the Benzodiazepine Site. 2 g x 4/day to 3.8 . Japanese Knotweed appears to be similar to bamboo and is a large plant that can be seen in countries in Eastern Asia like China, Japan, and Korea. I tend to use GI Detox more than activated charcoal because its non-constipating. Spirochetes can morph into cysts and cysts into spirochetes. The antibiotic is based on a compound found in soil. I got the Source Naturals brand. Infect Microb Dis. A lot of PANS kids will be sensitive to viruses, meaning that they will have flares when they come into contact with viruses. THE CORE BUHNER PROTOCOL FOR BARTONELLA INFECTIONS: Japanese knotweed root tincture (cytokine cascade reduction and endothelial cell protection) , 1/4-1/2 tsp 3x daily Because of its antibacterial properties, its actually pretty good for strep too. Essentially what happens is that the baseline symptoms intensify. In combination with Epsom salts with baking soda or Alka Seltzer gold, you can add binders independently. Tox-Ease from Beyond Balance is another one that I use often that is gentle and effective for managing die-off symptoms. It is primarily useful for cancer treatment because of its antioxidant nature but besides its conventional use it can also be used as an efficient measure against Lyme arthritis. Take the powder of Japanese knotweed one teaspoon (or it is also recommended for tablespoon), that mixed with juice 3 for times a day probably will be effective to heal lyme's disease. The capillary stimulant action is of specific importance in Lyme treatment as it increases the blood flow to areas where the Lyme spirochete likes to live such as the eyes, skin, heart and joints. About 90 percent of the time when antibiotics are started or changed during a treatment, a person will initially worsen. (Lyme, Babesia, & Bartonella Timelines), Herxheimer Die-off Reaction: Inflammation Run Amok, Best Tests and Laboratory for Tick-Borne Illnesses. I have found various pulse-dose regimens of tinidazole to work. Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening. Thanks. If this red blood cell antioxidant is low, then you should not take methylene blue. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine. They found the combination of doxycycline and Baicalein provided the additional benefit of being able to attack the latent, rounded form, not just the active dividing spirochete form of Borrelia. If using a tincture, general dosing is 1-2 mL up to three times daily. how long have you been on the protocol Questing? I encourage everyone to look into the cell danger response that Bob Navieux has been working, which essentially shows that the mitochondria are important for the immune system. DOI=10.3389/fmed.2020.00006. Monitor the symptoms and infection according to their intensity and effect. One regimen I offer is a Horowitz dapsone-persister regimen. Some folks even take them together, for example; TONIC in morning and afternoon, CORE in the evening. Before you start any treatment, consult a certified lyme expert! You can eat the stalks in early spring. Things you can do yourself, to make your life easier and you happier! Longer-term use could be months or years, depending on the severity of the illness. I recently stopped antibiotics and upped my JK. Herbs that are antimicrobial will likely set off a herxheimer reaction. LYME disease researchers are exploring the medical properties of Japanese knotweed, suggesting plant-based drugs could be a better treatment than antibiotics. For more information about this, see When Will I Start to Feel Better? On day two, you will start with one drop in the morning and add one drop in the afternoon. I use hooftinder polypore in this which also is good in Lyme treatment. Quantity - Following is a rough list for required dosages of Japanese Knotweed:- For a 150 pounds weighing adult - 1 teaspoon for 3 times in a day RESVERATROL ~ 2 capsules a day (400-500mg total per day) Try Garden of Life Raw trans resveratrol. Many people need longer courses of treatment and sometimes a mixture of natural interventions and mainstream. Not surprisingly they are both greatly feared and dreaded. The active ingredient in Ghanaian quinine is an alkaloid called cryptolepine, which people have traditionally used against malaria, hepatitis, septicemia, and tuberculosis. It can also be used to transform familiar recipes into exotic ones. In my practice, I offer two persister-oriented regimens for those that have failed years of regular antibiotics. Japanese Knotweed Root is a very strong inhibitor of cytokine cascades initiated by bacteria. Evidence assessments and guidelines recommendations in Lyme disease: The clinical management of known tick bites, erythema migrans rashes and persistent disease. The CDC estimates there are about 300,000 new cases of Lyme disease discovered each year in the United States. Dapsone for Lyme Persisters. Both regimens have some published clinical evidence of benefit. I started with 1 drop and slowly went up to 2 droppers full, 3 times a day. Effective treatments must use intracellular antibiotics to reach L-forms living inside cells. Thanks Louisa. This herbal medicine is traditionally used to treat Lyme, which Stephen Buhner recommends. Cryptolepis has the following properties: Artemisia annua (Sweet Wormwood) has been used medically for >2000 year. i'd take one day of no symptoms for $1000 Alex ;). More on endothelial protection may be found in the publication: Stephen Harrod Buhner "Healing Lyme: Natural Healing of Lyme Borreliosis and the Coinfections Chlamydia and Spotted Fever Ricettsioses." Second edition. It has been shown in studies to have strong activity against the stationary form of borrelia burgdorferi. The active constituent has been documented to have activity against the stationary form of Borrelia. Artemisia, also known as sweet wormwood, has been used medicinally for over 2000 years. Essential oils are very powerful; think about how much plant material is necessary to produce one ounce of essential oil. Rarely, the rash can be painful or itchy. ), overwhelming feelings of depression and anxiety justdont go away. treats all growth phases of Lyme at the same time. Mar 18, 2013 | dosage info, Herbs, japanese knotweed, The Basics | 26 comments. Essentially resveratrol is a potent antioxidant, has anti-inflammatory, neuroprotective, and cardioprotective properties. Nutrition Value Knotweed is rich source of Vitamin A, Vitamin C, and antioxidant flavonoid rutin. 2016;7(3):1000345. doi:10.4172/2155-9554.1000345, Li T, Feng J, Xiao S, Shi W, Sullivan D, Zhang Y. I highly recommend Buhner's book Healing Lyme (2nd edition) to . Grapefruit seed extract is better tolerated than both tinidazole and metronidazole and supports killing of Lyme cysts. This herbal medicine is traditionally used to treat Lyme and Bartonella as described in the various books by master herbalist Stephen Buhner. I usually start with Japanese Knotweed and my Cats Claw. What is Japanese Knotweed? Its active constituent ARTEMISININ is famous Was recognized in 2015 with a Nobel Prize from its role in treating malaria! You can even send a message about the hiccup, that would be awesome! More detail on Chinese Skullcap is included further on in this article. I use pretty often for my mycoplasma kiddos with pans or just active mycoplasma in general. Its a monthly protocol that utilizes about 14 different Nutramedix products on a rotational basis; its a very specific protocol. Continue treatment with antibiotics until you are well. On average, it can take two years to recover for someone with chronic Lyme. A herxheimer reaction is actually a good thing. 2020;9(12):868. doi:10.3390/antibiotics9120868(, Goc A, Rath M. The anti-Borreliae efficacy of phytochemicals and micronutrients: An update. If your pet has a chronic condition you can easily level up to the next species to increase the dose. Clinically, I see great benefit in using the rifamycins as my anti-cyst agents, so I list them here. Join us by subscribing to our newsletter. For the rifamycins, no laboratory experiments show these agents work against cysts. In early treatment of the disease, infection and symptoms can be removed by antibiotics but delayed or inadequate treatment can result into more serious symptoms, which can be difficult to treat. Has been known to help relieve the pain associated with Lyme disease and chronic fatigue. Also, it is also anti-microbial, protects the central nervous system, clears out endotoxins, anti oxidant, and is . Minocycine and rifampin in this combination are also useful for treating a Bartonella co-infection. I'm on Flagyl, so I can't do any alcohol based tinctures. All Rights Reserved. Schlechter. I'm not sure what's going on with me. ), This is a pulse-dose regimen of the tinidazole. Treating persisters is a newer area in Lyme treatment. Dr. Lindsey Wells is a naturopathic physician. My favorite binder is GI Detox by Biobotanical research. I always try to find treatments with multiple benefits so we can hit multiple issues with one product, rather than adding so many products. Can diet help improve depression symptoms? Dr. Zhang and colleagues have shown these oils are effective at treating growing and persister states of Lyme and Bartonella. Cats claw has antiviral properties. It kills the spirochetes that are found in difficult-to-reach areas by enhancing the blood flow and also helps other drugs to be more effective. Unlike an extract, Japanese Knotweed also contains other beneficial . A small percentage of patients can get into remission with this treatment. You will need to take an enzyme to help dissolve the biofilm of the cysts, in order for the Lyme to be killed off. Its also one thats used very often for Bartonella infections, and it has a naturally occurring constituent known as resveratrol. These steps are designed to revive health and to boost the immune system. . Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi. This means treatments should include antimicrobials that address persisters, in addition to the growth phase of the germ. 2016 Jul 22. doi:10.7150/ijbs.16060. Dr. I did Japanese Knotweed in tincture form. The disease spreads to humans through the bite of a tick that carries the bacterium, and it affects an estimated 300,000 people each year in the U.S. alone. The use of dapsone as a novel persister drug in the treatment of chronic Lyme disease/post treatment Lyme disease syndrome. I have been taking it because I don't have access to anti-biotics and am working towards balance via herbs and began with the buhner protocol. Each of these herbal medicine options is shown in lab experiments to treat growing and persister phases of Lyme. With Optimism, life is good! Here is a list of prescription medications shown in human experiments to help with persister Lyme. In my practice, I often mix herbal and prescription options together. This may be the reason there is so much chronic Lyme disease. Japanese Knotweed- 7000mg per day = 10 capsules Cat's Claw - 7000 mg per day = 10 capsules Eleutherococcus - 4200 mg per day = 6 capsules Note- I took a 2 week break every 60 days I began with one herb at a time. The ideas and recommendations on this website and in this article are for informational purposes only. 2016;10:13071322. Its properties include it is neuroprotective, anti-inflammatory, and DNA repair. They then reviewed which studies showed those herbs having benefits against Borrelia burgdorferi. Byron White recommends starting is using Detox-2, which is a binder. It has been identified in high concentrations as a strong flavonoid, at the roots of the plant. but you can search by your area and look at the doctors that have Adult and Lyme both clicked on the choices. If Lyme is untreated then later symptoms may involve heart, joints, and central nervous system. Therefore, it is worth considering the addition of these natural substances with the use of doxycycline for a more comprehensive and effective antimicrobial action. ASPIRE Facebook Group & ChitChat Meetings, Clinical Urgency of Diagnosing & Treating, Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi, n Vitro Effectiveness of Samento and Banderol Herbal Extracts on the Different Morphological Forms of Borrelia Burgdorferi, Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of, http://aspire.care/treating-pans/find-a-provider/, http://aspire.care/treating-pans/find-a-provider/Only, https://www.ilads.org/patient-care/provider-search/, http://aspire.care/featured/overview-of-lyme-tick-borne-illness/, http://aspire.care/featured/lyme-disease-tick-coinfections/, Webinar Daniel A. Kinderlehrer, MD Microbes and Mental Illness: Tick-Borne Infections and PANS, Webinar Marla W. Deibler, PsyD, ABPP- Maximizing Family Support in PANS / PANDAS, Finding PANS PANDAS Treatment as an Adult, Antibiotics are the standard of care for Lyme Disease, It is reported that 10-20% of people continue to suffer from Lyme Disease symptoms after antibiotic treatment, Antibiotics are most effective against the dividing spirochete form of B. burgdorferi, However, B. burgdorferi can change its form depending on the conditions for survival, These additional forms contain stationary persister forms and biofilms, Lyme Disease can be challenging to treat due to its ability to change forms as a protective mechanism, Doxycycline is the standard of care for treatment of Lyme Disease, Doxycycline is effective against the active form of Borrelia but less effective against biofilms and latent rounded forms, Doxycycline combined with Baicalein exhibits additional antimicrobial benefits against the latent rounded form of Borrelia, Baicalein is the active constituent found in the herb Chinese Skullcap Doxycycline in combination with iodine demonstrated benefits against spirochetes and biofilms, Food sources of iodine include iodized salt, seaweed, seafood. Start with taking low dosages, and increase the dosages gradually, in weeks. Due to very few researches done on the resveratrol consumption in humans, doctors are not able to confirm any benefits or effects over the long term. Learn more about transmission, prevention, and the symptoms in this. Can you help me? Category : Blog, Featured on Homepage, Tick-Borne Illness. EGCG with quercetin is another good choice. These options are ones I am using with various degrees of success in my Seattle practice. 2023 Healthline Media UK Ltd, Brighton, UK. 2nd day: 2 x 1 drop per day. Antibiotics (Basel). It is also compounded as a 62.5 mg pill. At the same time, some of the other natural compounds that the researchers tested offered insignificant or no results. This is a really nice formula that can be supportive when you start to add in different herbs. Refer to Herxheimer Die-off Reaction: Inflammation Run Amok for a discussion of this and practical steps you can take to prevent or treat it. Lyme disease is the most common vector-borne disease in the US and Europe. Once I got to the full dosage for my weight I started the next herb. Many have found it to be an effective treatment . The general suggested dosage for a Japanese knotweed powdered extract is 200-800 mg ( standardized to 50% trans-resveratrol) two to three times daily. Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Persistent Forms of Borrelia sp. These are known as persister cells. One form is the spirochete and the other is a microscopic cyst. Fortunately, intracellular antibiotics also reach Lyme outside of cells, too. These were colloidal silver, monoglyceride monolaurin, and the antimicrobial peptide LL37 also found human immune cells. Some other herbs or drugs can also be consumed along the knotweed to enhance the medication required for the proper removal of Lyme causing bacteria. I usually start patients at 62.5 mg every third day for 10 days, then I advance to 62.5 mg every other day for 10 days, then to 62.5 mg 1 time a day. I have been referred to numerous specialists (Endocrinologists, Neurologists, etc.) Sida Acuta, I dont use it as often because some people have a reaction to it; you should work with a practitioner if you choose to add it. Monoglyceride monolaurin, and central nervous system more about transmission, prevention, and is are. 18, 2013 | dosage info, herbs, japanese Knotweed ( Fallopia japonica, seaweed. Is gentle and effective for managing die-off symptoms this herbal medicine options is shown in lab to... Someone with chronic Lyme disease discovered each year in the US and Europe so much Lyme! Changed during a treatment, consult a certified Lyme expert could be months or years, depending on severity! Are about 300,000 new cases of Lyme treating malaria lab experiments to treat and. 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Chronic condition you can even send a message about the hiccup, that be... Nutrition Value Knotweed is rich source of Vitamin a, Vitamin C, and antioxidant flavonoid.... Lyme treatment a message about the hiccup, that would be awesome evidence of benefit Lyme cysts started changed. Have strong activity against the stationary form of Borrelia burgdorferi a potent antioxidant has!